Fresh analysis indicates that patients who discontinue popular GLP-1 drugs like Mounjaro or Wegovy may regain reduced body mass much more quickly than those who stop traditional diet and exercise plans.
Research printed in a leading health publication demonstrates that while obese individuals often shed substantial amounts of their body weight while undergoing treatment, the weight returns at an estimated rate of 0.8 kg per month upon discontinuation.
"Users purchasing such medications must be informed of the risk of rapid rebound weight gain when the treatment is stopped," warns researcher Dr. Susan Jebb.
This pace of regain implies a reversion to starting weight in about 18 months.
Weighing Therapies
The study, which looked at 37 of studies involving thousands of participants, compared the outcomes of the injectable medications with other pills.
The team emphasize that individuals who lose weight through dieting usually experience a more gradual creep back—approximately 100 grams monthly—after stopping.
Explaining the Rapid Rebound
Experts believe the way of the injections explains the heightened rebound.
These medications mimic a natural hormone called GLP-1, which controls appetite.
"Sustained high doses of GLP-1 levels far above than normal might result in the system to generate a reduced amount of its endogenous GLP-1, and could reduce responsiveness to its actions," explained Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this hormone supplement means appetite is no longer kept in check, making overeating much more probable."
A Chronic Disease?
Health authorities recommend the jabs for individuals with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Many experts argue that, considering the significant potential of relapse, the treatment might need to be long-term.
This perspective is echoed by drug manufacturers, who note that the results "highlight the chronic character of obesity," akin to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have discontinued the jabs report a powerful return of hunger.
"It felt as if something activating and you're instantly ravenous," recalled an individual.
The struggle is exacerbated if patients have not established permanent dietary or behavioural changes during treatment.
Significant Use
Figures show that a significant number of people in the UK have tried these injections in the past year, with desire continuing to grow.
- Use is higher among women compared to males.
- The 40s and 50s demographic shows the greatest level of interest.
- Many access the medications through private prescriptions rather than the NHS.
In conclusion, researchers stress that while these medications are potent agents for shedding pounds, they are not a standalone cure and lasting health benefits relies on integrated lifestyle support.
